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Overexpression of PAX4 reduces glucagon expression in differentiating hESCs
Human embryonic stem cells (hESCs) are pluripotent and capable of generating new β-cells, but current in vitro differentiation protocols generally fail to produce mature, glucose-responsive, unihormonal β-cells. Instead, these methods tend to produce immature polyhormonal endocrine cells which matur...
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| Publicado no: | Islets |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4594199/ https://ncbi.nlm.nih.gov/pubmed/25483960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.29236 |
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