Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity

Breast cancers (BCs) typically express estrogen receptors (ERs) but frequently exhibit de novo or acquired resistance to hormonal therapies. Here, we show that short-term treatment with the anti-estrogens tamoxifen or fulvestrant decrease cell proliferation but increase BC stem cell (BCSC) activity...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Simões, Bruno M., O’Brien, Ciara S., Eyre, Rachel, Silva, Andreia, Yu, Ling, Sarmiento-Castro, Aida, Alférez, Denis G., Spence, Kath, Santiago-Gómez, Angélica, Chemi, Francesca, Acar, Ahmet, Gandhi, Ashu, Howell, Anthony, Brennan, Keith, Rydén, Lisa, Catalano, Stefania, Andó, Sebastiano, Gee, Julia, Ucar, Ahmet, Sims, Andrew H., Marangoni, Elisabetta, Farnie, Gillian, Landberg, Göran, Howell, Sacha J., Clarke, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594158/
https://ncbi.nlm.nih.gov/pubmed/26387946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.050
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