Eculizumab in Pediatric Dense Deposit Disease

BACKGROUND AND OBJECTIVES: Dense deposit disease (DDD), a subtype of C3 glomerulopathy, is a rare disease affecting mostly children. Treatment options are limited. Debate exists whether eculizumab, a monoclonal antibody against complement factor C5, is effective in DDD. Reported data are scarce, esp...

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Pubblicato in:Clin J Am Soc Nephrol
Autori principali: Oosterveld, Michiel J.S., Garrelfs, Mark R., Hoppe, Bernd, Florquin, Sandrine, Roelofs, Joris J.T.H., van den Heuvel, L.P., Amann, Kerstin, Davin, Jean-Claude, Bouts, Antonia H.M., Schriemer, Pietrik J., Groothoff, Jaap W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2015
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594061/
https://ncbi.nlm.nih.gov/pubmed/26316621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2215/CJN.01360215
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