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Tuning hERG out: Antitarget QSAR Models for Drug Development
Several non-cardiovascular drugs have been withdrawn from the market due to their inhibition of hERG K(+) channels that can potentially lead to severe heart arrhythmia and death. As hERG safety testing is a mandatory FDA-required procedure, there is a considerable interest for developing predictive...
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Published in: | Curr Top Med Chem |
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Main Authors: | , , , , , , |
Format: | Artigo |
Language: | Inglês |
Published: |
2014
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Subjects: | |
Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4593700/ https://ncbi.nlm.nih.gov/pubmed/24805060 |
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