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Tuning hERG out: Antitarget QSAR Models for Drug Development

Several non-cardiovascular drugs have been withdrawn from the market due to their inhibition of hERG K(+) channels that can potentially lead to severe heart arrhythmia and death. As hERG safety testing is a mandatory FDA-required procedure, there is a considerable interest for developing predictive...

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Bibliographic Details
Published in:Curr Top Med Chem
Main Authors: Braga, Rodolpho C., Alves, Vinícius M., Silva, Meryck F. B., Muratov, Eugene, Fourches, Denis, Tropsha, Alexander, Andrade, Carolina H.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593700/
https://ncbi.nlm.nih.gov/pubmed/24805060
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