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Integration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product libraries
Traditional natural products discovery using a combination of live/dead screening followed by iterative bioassay-guided fractionation affords no information about compound structure or mode of action until late in the discovery process. This leads to high rates of rediscovery and low probabilities o...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4593099/ https://ncbi.nlm.nih.gov/pubmed/26371303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507743112 |
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