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Synthetic dosage lethality in the human metabolic network is highly predictive of tumor growth and cancer patient survival
Synthetic dosage lethality (SDL) denotes a genetic interaction between two genes whereby the underexpression of gene A combined with the overexpression of gene B is lethal. SDLs offer a promising way to kill cancer cells by inhibiting the activity of SDL partners of activated oncogenes in tumors, wh...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4593091/ https://ncbi.nlm.nih.gov/pubmed/26371301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508573112 |
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