Antiplatelet Aggregation and Antithrombosis Efficiency of Peptides in the Snake Venom of Deinagkistrodon acutus: Isolation, Identification, and Evaluation

Two peptides of Pt-A (Glu-Asn-Trp 429 Da) and Pt-B (Glu-Gln-Trp 443 Da) were isolated from venom liquor of Deinagkistrodon acutus. Their antiplatelet aggregation effects were evaluated with platelet-rich human plasma in vitro; the respective IC(50) of Pt-A and Pt-B was 66 μM and 203 μM. Both peptide...

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Veröffentlicht in:Evid Based Complement Alternat Med
Hauptverfasser: Ding, Bin, Xu, Zhenghong, Qian, Chaodong, Jiang, Fusheng, Ding, Xinghong, Ruan, Yeping, Ding, Zhishan, Fan, Yongsheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592893/
https://ncbi.nlm.nih.gov/pubmed/26483843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/412841
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