ATR Plays a Direct Antiapoptotic Role at Mitochondria Which Is Regulated by Prolyl Isomerase Pin1

ATR, a PI3K-like protein kinase, plays a key role in regulating DNA damage responses. Its nuclear checkpoint kinase function is well documented but little is known about its function outside the nucleus. Here we report that ATR has an antiapoptotic activity at mitochondria in response to UV damage,...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Hilton, Benjamin A., Li, Zhengke, Musich, Phillip R., Wang, Hui, Cartwright, Brian M., Serrano, Moises, Zhou, Xiao Zhen, Lu, Kun Ping, Zou, Yue
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592481/
https://ncbi.nlm.nih.gov/pubmed/26387736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.08.008
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