Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy

INTRODUCTION: Prostate-specific antigen (PSA) testing is a widely accepted screening method for prostate cancer, but with low specificity at thresholds giving good sensitivity. Previous research identified four single nucleotide polymorphisms (SNPs) principally associated with circulating PSA levels...

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Pubblicato in:PLoS One
Autori principali: Gilbert, Rebecca, Martin, Richard M., Evans, David M., Tilling, Kate, Davey Smith, George, Kemp, John P., Lane, J. Athene, Hamdy, Freddie C., Neal, David E., Donovan, Jenny L., Metcalfe, Chris
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592274/
https://ncbi.nlm.nih.gov/pubmed/26431041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136735
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