The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate

NF449, a sulfated compound derived from the antiparasitic drug suramin, was previously reported to inhibit infection by enterovirus A71 (EV-A71). In the current work, we found that NF449 inhibits virus attachment to target cells, and specifically blocks virus interaction with two identified receptor...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Nishimura, Yorihiro, McLaughlin, Noel P., Pan, Jieyan, Goldstein, Sara, Hafenstein, Susan, Shimizu, Hiroyuki, Winkler, Jeffrey D., Bergelson, Jeffrey M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592248/
https://ncbi.nlm.nih.gov/pubmed/26430888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005184
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados