Plasticity in chromosome number and testing of essential genes in Leishmania by targeting.
We attempted to generate homozygous dhfr-ts (dihydrofolate reductase-thymidylate synthase) knockouts in virulent Leishmania major, an asexual diploid protozoan parasite. Transfection of a neo (neomycin phosphotransferase) targeting fragment yielded heterozygous replacement lines with high efficiency...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45922/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8381972/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.4.1599 |
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