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Ligand uptake in Mycobacterium tuberculosis truncated hemoglobins is controlled by both internal tunnels and active site water molecules

Mycobacterium tuberculosis, the causative agent of human tuberculosis, has two proteins belonging to the truncated hemoglobin (trHb) family. Mt-trHbN presents well-defined internal hydrophobic tunnels that allow O (2) and (•)NO to migrate easily from the solvent to the active site, whereas Mt-trHbO...

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Bibliografski detalji
Izdano u:F1000Res
Glavni autori: Boron, Ignacio, Bustamante, Juan Pablo, Davidge, Kelly S, Singh, Sandip, Bowman, Lesley AH, Tinajero-Trejo, Mariana, Carballal, Sebastián, Radi, Rafael, Poole, Robert K, Dikshit, Kanak, Estrin, Dario A, Marti, Marcelo A, Boechi, Leonardo
Format: Artigo
Jezik:Inglês
Izdano: F1000Research 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591903/
https://ncbi.nlm.nih.gov/pubmed/26478812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.5921.2
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