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Ligand uptake in Mycobacterium tuberculosis truncated hemoglobins is controlled by both internal tunnels and active site water molecules

Mycobacterium tuberculosis, the causative agent of human tuberculosis, has two proteins belonging to the truncated hemoglobin (trHb) family. Mt-trHbN presents well-defined internal hydrophobic tunnels that allow O (2) and (•)NO to migrate easily from the solvent to the active site, whereas Mt-trHbO...

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Τόπος έκδοσης:	F1000Res
Κύριοι συγγραφείς:	Boron, Ignacio, Bustamante, Juan Pablo, Davidge, Kelly S, Singh, Sandip, Bowman, Lesley AH, Tinajero-Trejo, Mariana, Carballal, Sebastián, Radi, Rafael, Poole, Robert K, Dikshit, Kanak, Estrin, Dario A, Marti, Marcelo A, Boechi, Leonardo
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	F1000Research 2015
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4591903/ https://ncbi.nlm.nih.gov/pubmed/26478812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.5921.2
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Ligand uptake in Mycobacterium tuberculosis truncated hemoglobins is controlled by both internal tunnels and active site water molecules

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