Ligand uptake in Mycobacterium tuberculosis truncated hemoglobins is controlled by both internal tunnels and active site water molecules

Mycobacterium tuberculosis, the causative agent of human tuberculosis, has two proteins belonging to the truncated hemoglobin (trHb) family. Mt-trHbN presents well-defined internal hydrophobic tunnels that allow O (2) and (•)NO to migrate easily from the solvent to the active site, whereas Mt-trHbO...

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Bibliografische gegevens
Gepubliceerd in:F1000Res
Hoofdauteurs: Boron, Ignacio, Bustamante, Juan Pablo, Davidge, Kelly S, Singh, Sandip, Bowman, Lesley AH, Tinajero-Trejo, Mariana, Carballal, Sebastián, Radi, Rafael, Poole, Robert K, Dikshit, Kanak, Estrin, Dario A, Marti, Marcelo A, Boechi, Leonardo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: F1000Research 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591903/
https://ncbi.nlm.nih.gov/pubmed/26478812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.5921.2
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