Ligand uptake in Mycobacterium tuberculosis truncated hemoglobins is controlled by both internal tunnels and active site water molecules

Mycobacterium tuberculosis, the causative agent of human tuberculosis, has two proteins belonging to the truncated hemoglobin (trHb) family. Mt-trHbN presents well-defined internal hydrophobic tunnels that allow O (2) and (•)NO to migrate easily from the solvent to the active site, whereas Mt-trHbO...

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Détails bibliographiques
Publié dans:F1000Res
Auteurs principaux: Boron, Ignacio, Bustamante, Juan Pablo, Davidge, Kelly S, Singh, Sandip, Bowman, Lesley AH, Tinajero-Trejo, Mariana, Carballal, Sebastián, Radi, Rafael, Poole, Robert K, Dikshit, Kanak, Estrin, Dario A, Marti, Marcelo A, Boechi, Leonardo
Format: Artigo
Langue:Inglês
Publié: F1000Research 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591903/
https://ncbi.nlm.nih.gov/pubmed/26478812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.5921.2
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