Glutamate Transporter Homolog-based Model Predicts That Anion-π Interaction Is the Mechanism for the Voltage-dependent Response of Prestin

Prestin is the motor protein of cochlear outer hair cells. Its unique capability to perform direct, rapid, and reciprocal electromechanical conversion depends on membrane potential and interaction with intracellular anions. How prestin senses the voltage change and interacts with anions are still un...

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Udgivet i:J Biol Chem
Main Authors: Lovas, Sándor, He, David Z. Z., Liu, Huizhan, Tang, Jie, Pecka, Jason L., Hatfield, Marcus P. D., Beisel, Kirk W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591817/
https://ncbi.nlm.nih.gov/pubmed/26283790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.649962
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