Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy

Intravascular hemolysis and hemoglobinuria are associated with sickle cell nephropathy. ApoL1 is involved in cell-free hemoglobin scavenging through association with haptoglobin-related protein. APOL1 G1/G2 variants are the strongest genetic predictors of kidney disease in the general African-Americ...

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Publicado en:Haematologica
Autores principales: Saraf, Santosh L., Zhang, Xu, Shah, Binal, Kanias, Tamir, Gudehithlu, Krishnamurthy P., Kittles, Rick, Machado, Roberto F., Arruda, Jose A.L., Gladwin, Mark T., Singh, Ashok K., Gordeuk, Victor R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2015
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591759/
https://ncbi.nlm.nih.gov/pubmed/26206798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.124875
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