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Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote breast cancer cell invasion

Up-regulation of the cytoskeleton linker protein ezrin frequently occurs in aggressive cancer types and is closely linked with metastatic progression. However, the underlying molecular mechanisms detailing how ezrin is involved in the invasive and metastatic phenotype remain unclear. Here we report...

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Bibliografiske detaljer
Udgivet i:Mol Biol Cell
Main Authors: Hoskin, Victoria, Szeto, Alvin, Ghaffari, Abdi, Greer, Peter A., Côté, Graham P., Elliott, Bruce E.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591691/
https://ncbi.nlm.nih.gov/pubmed/26246600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-12-1584
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