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Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast
DNA replication stress causes genome mutations, rearrangements, and chromosome missegregation, which are implicated in cancer. We analyze a fission yeast mutant that is unable to complete S phase due to a defective subunit of the MCM helicase. Despite underreplicated and damaged DNA, these cells eva...
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| Udgivet i: | Mol Biol Cell |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Cell Biology
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4591689/ https://ncbi.nlm.nih.gov/pubmed/26246602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-05-0318 |
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