Arterial α(2)-Na(+) pump expression influences blood pressure: lessons from novel, genetically engineered smooth muscle-specific α(2) mice

Arterial myocytes express α(1)-catalytic subunit isoform Na(+) pumps (75–80% of total), which are ouabain resistant in rodents, and high ouabain affinity α(2)-Na(+) pumps. Mice with globally reduced α(2)-pumps (but not α(1)-pumps), mice with mutant ouabain-resistant α(2)-pumps, and mice with a smoot...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Chen, Ling, Song, Hong, Wang, Youhua, Lee, Jane C., Kotlikoff, Michael I., Pritchard, Tracy J., Paul, Richard J., Zhang, Jin, Blaustein, Mordecai P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591399/
https://ncbi.nlm.nih.gov/pubmed/26209057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00430.2015
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