Disabling of the erbB Pathway Followed by IFN-γ Modifies Phenotype and Enhances Genotoxic Eradication of Breast Tumors

Reversion of the malignant phenotype of erbB2-transformed cells can be driven by anti-erbB2/neu monoclonal antibodies (mAb), which disrupt the receptor's kinase activity. We examined the biologic effects of IFN-γ alone or after anti-erbB2/neu mAb treatment of erbB2-positive cells. IFN-γ had no...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Nagai, Yasuhiro, Tsuchiya, Hiromichi, Runkle, E. Aaron, Young, Peter D., Ji, Mei Q., Norton, Larry, Drebin, Jeffrey A., Zhang, Hongtao, Greene, Mark I.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591220/
https://ncbi.nlm.nih.gov/pubmed/26365188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.044
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