Natural small molecule FMHM inhibits lipopolysaccharide-induced inflammatory response by promoting TRAF6 degradation via K48-linked polyubiquitination

TNF receptor-associated factor 6 (TRAF6) is a key hub protein involved in Toll-like receptor-dependent inflammatory signaling pathway, and it recruits additional proteins to form multiprotein complexes capable of activating downstream NF-κB inflammatory signaling pathway. Ubiquitin-proteasome system...

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Vydáno v:Sci Rep
Hlavní autoři: Zeng, Ke-Wu, Liao, Li-Xi, Lv, Hai-Ning, Song, Fang-Jiao, Yu, Qian, Dong, Xin, Li, Jun, Jiang, Yong, Tu, Peng-Fei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589686/
https://ncbi.nlm.nih.gov/pubmed/26423026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14715
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