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Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions

Multiple attributes of the three-dimensional (3D) extracellular matrix (ECM) have been independently implicated as regulators of cell motility, including pore size, crosslink density, structural organization, and stiffness. However, these parameters cannot be independently varied within a complex 3D...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fraley, Stephanie I., Wu, Pei-hsun, He, Lijuan, Feng, Yunfeng, Krisnamurthy, Ranjini, Longmore, Gregory D., Wirtz, Denis
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589685/
https://ncbi.nlm.nih.gov/pubmed/26423227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14580
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