Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice

AIMS/HYPOTHESIS: Glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonism, used in the treatment of type 2 diabetes, has recently been shown to increase thermogenesis via the brain. As brown adipose tissue (BAT) produces heat by burning triacylglycerol (TG) and takes up glucose for de novo lipogene...

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Pubblicato in:Diabetologia
Autori principali: Kooijman, Sander, Wang, Yanan, Parlevliet, Edwin T., Boon, Mariëtte R., Edelschaap, David, Snaterse, Gido, Pijl, Hanno, Romijn, Johannes A., Rensen, Patrick C. N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589565/
https://ncbi.nlm.nih.gov/pubmed/26254578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-015-3727-0
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