Phenotypic Knockout of CXCR4 Expression by a Novel Intrakine Mutant hSDF-1α/54/KDEL Inhibits Breast Cancer Metastasis

Many malignant tumors express high levels of the chemokine receptor CXCR4, and the interaction between CXCR4 and its ligand, SDF-1, promotes migration, invasion, and metastasis of breast cancer cells. Therefore, blocking the interaction between CXCR4 and SDF-1 could alter the tumor's metastatic...

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Bibliographic Details
Published in:J Interferon Cytokine Res
Main Authors: Chen, Hong-Yuan, Clayman, Eric S., Ma, Wei-Feng
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2015
Subjects:
Research Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589268/
https://ncbi.nlm.nih.gov/pubmed/25978539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2014.0141
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