In vitro Characterization of the Rapid Cytotoxicity of Anticancer Peptide HPRP-A2 through Membrane Destruction and Intracellular Mechanism against Gastric Cancer Cell Lines

In this study, HPRP-A2, a synthetic 15-mer cationic peptides with all D-amino acids, effectively inhibited the survival of gastric cell lines in a dose-dependent manner. Gastric tumor cells killing by HPRP-A2 involves a rapid collapse of the membrane integrity and intracellular pathways. Propidium i...

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Vydáno v:PLoS One
Hlavní autoři: Zhao, Jing, Hao, Xueyu, Liu, Dong, Huang, Yibing, Chen, Yuxin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589244/
https://ncbi.nlm.nih.gov/pubmed/26422386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139578
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