Evolutionary Changes of Hepatitis B Virus Pre-S Mutations Prior to Development of Hepatocellular Carcinoma

BACKGROUND AND AIMS: Deletions/mutations in the hepatitis B virus (HBV) pre-S region have been associated with hepatocellular carcinoma (HCC). We aimed to study the evolutionary changes of pre-S mutations prior to HCC development. METHODS: We studied the HBV pre-S sequences at 1 to 10 years precedin...

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Pubblicato in:PLoS One
Autori principali: Zhang, An-Ye, Lai, Ching-Lung, Huang, Fung-Yu, Seto, Wai-Kay, Fung, James, Wong, Danny Ka-Ho, Yuen, Man-Fung
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589234/
https://ncbi.nlm.nih.gov/pubmed/26421619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139478
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