Anergic bone marrow Vγ9Vδ2 T cells as early and long-lasting markers of PD-1-targetable microenvironment-induced immune suppression in human myeloma

Vγ9Vδ2 T cells have a natural inclination to recognize malignant B cells in vitro via receptors for stress-induced self-ligands and TCR-dependent recognition of phosphoantigens (pAgs) generated in the mevalonate (Mev) pathway. This inclination is continuously challenged in vivo by the immune suppres...

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Vydáno v:Oncoimmunology
Hlavní autoři: Castella, Barbara, Foglietta, Myriam, Sciancalepore, Patrizia, Rigoni, Micol, Coscia, Marta, Griggio, Valentina, Vitale, Candida, Ferracini, Riccardo, Saraci, Elona, Omedé, Paola, Riganti, Chiara, Palumbo, Antonio, Boccadoro, Mario, Massaia, Massimo
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589055/
https://ncbi.nlm.nih.gov/pubmed/26451323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1047580
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