Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis

The platelet receptor CLEC-2 is involved in thrombosis/hemostasis, but its ligand, podoplanin, is expressed only in advanced atherosclerotic lesions. We investigated CLEC-2 ligands in vessel walls. Recombinant CLEC-2 bound to early atherosclerotic lesions and normal arterial walls, co-localizing wit...

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Veröffentlicht in:PLoS One
Hauptverfasser: Inoue, Osamu, Hokamura, Kazuya, Shirai, Toshiaki, Osada, Makoto, Tsukiji, Nagaharu, Hatakeyama, Kinta, Umemura, Kazuo, Asada, Yujiro, Suzuki-Inoue, Katsue, Ozaki, Yukio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587843/
https://ncbi.nlm.nih.gov/pubmed/26418160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139357
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