PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells

PURPOSE: AKT plays a pivotal role in the signal transduction of cancer cells. MK2206, an AKT inhibitor, has been shown to be an effective anti-cancer drug to a variety of cancer cell lines. However, some cancer cells acquire resistance to MK2206 and new strategies to suppress these cell lines remain...

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Vydáno v:Cancer Cell Int
Hlavní autoři: Qi, Lei, Toyoda, Hidemi, Xu, Dong-qing, Zhou, Ye, Sakurai, Naoto, Amano, Keishirou, Kihira, Kentaro, Hori, Hiroki, Azuma, Eiichi, Komada, Yoshihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Primary Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587771/
https://ncbi.nlm.nih.gov/pubmed/26421002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-015-0239-4
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