The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein

BACKGROUND: Since the identification of poly-alanine expanded poly(A) binding protein nuclear 1 (PABPN1) as the genetic cause of oculopharyngeal muscular dystrophy (OPMD), considerable progress has been made in our understanding of the pathogenesis of the disease. However, the molecular mechanisms t...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Shi, Chao, Huang, Xuan, Zhang, Bin, Zhu, Dan, Luo, Huqiao, Lu, Quqin, Xiong, Wen-Cheng, Mei, Lin, Luo, Shiwen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587574/
https://ncbi.nlm.nih.gov/pubmed/26414348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138936
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