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Pharmacological Regulation of SPARC by Lovastatin in Human Trabecular Meshwork Cells

PURPOSE. Statins have been shown to increase aqueous outflow facility. The matricellular protein SPARC (secreted protein acidic and rich in cysteine) is a critical mediator of aqueous outflow and intraocular pressure (IOP). Here, we examine the effects of lovastatin on SPARC expression in trabecular...

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Bibliografske podrobnosti
izdano v:Invest Ophthalmol Vis Sci
Main Authors: Villarreal, Guadalupe, Chatterjee, Ayan, Oh, Sarah S., Oh, Dong-Jin, Rhee, Douglas J.
Format: Artigo
Jezik:Inglês
Izdano: The Association for Research in Vision and Ophthalmology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586968/
https://ncbi.nlm.nih.gov/pubmed/24474275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-12712
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