Regional Intraosseous Administration of Prophylactic Antibiotics is More Effective Than Systemic Administration in a Mouse Model of TKA

BACKGROUND: In human TKA studies, intraosseous regional administration (IORA) of prophylactic antibiotics achieves local tissue antibiotic concentrations 10 times greater than systemic administration. However, it is unclear if such high concentrations provide more effective prophylaxis. QUESTIONS/PU...

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Detalhes bibliográficos
Publicado no:Clin Orthop Relat Res
Main Authors: Young, Simon W., Roberts, Tim, Johnson, Sarah, Dalton, James P., Coleman, Brendan, Wiles, Siouxsie
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586203/
https://ncbi.nlm.nih.gov/pubmed/26224291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11999-015-4464-x
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