Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females

In this study we applied a new analytical strategy to investigate the relations between stochastic epigenetic mutations (SEMs) and aging. We analysed methylation levels through the Infinium HumanMethylation27 and HumanMethylation450 BeadChips in a population of 178 subjects ranging from 3 to 106 yea...

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Detaylı Bibliyografya
Yayımlandı:Aging (Albany NY)
Asıl Yazarlar: Gentilini, Davide, Garagnani, Paolo, Pisoni, Serena, Bacalini, Maria Giulia, Calzari, Luciano, Mari, Daniela, Vitale, Giovanni, Franceschi, Claudio, Di Blasio, Anna Maria
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2015
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586102/
https://ncbi.nlm.nih.gov/pubmed/26342808
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