DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression

Heat shock response (HSR) is an essential host-defense mechanism that is dysregulated in obesity-induced insulin resistance and type 2 diabetes (T2D). Our recent data demonstrated that DNAJB3 was downregulated in obese human subjects and showed negative correlation with inflammatory markers. Neverth...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Abu-Farha, Mohamed, Cherian, Preethi, Al-Khairi, Irina, Tiss, Ali, Khadir, Abdelkrim, Kavalakatt, Sina, Warsame, Samia, Dehbi, Mohammed, Behbehani, Kazem, Abubaker, Jehad
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585859/
https://ncbi.nlm.nih.gov/pubmed/26400768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14448
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