Sensorimotor gating impairments induced by MK-801 treatment may be reduced by tolerance effect and by familiarization in monkeys

Dizocilpine (MK-801) is a non-competitive NMDA antagonist that induces schizophreniclike effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. I...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Saletti, Patricia G., Maior, Rafael S., Hori, Etsuro, Nishijo, Hisao, Tomaz, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585034/
https://ncbi.nlm.nih.gov/pubmed/26441660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00204
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