Insulin-like growth factor binding protein-3 mediates interleukin-24-induced apoptosis through inhibition of the mTOR pathway in prostate cancer

IGF-binding protein-3 (IGFBP-3) has been shown to induce apoptosis in an insulin-like growth factor (IGF)-independent manner in various cell systems, however, the underlying molecular mechanisms remain unknown. In the present study, we showed that IGFBP-3 significantly enhanced interleukin-24 (IL-24...

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Vydáno v:Oncol Rep
Hlavní autoři: DU, YUEFENG, LONG, QINGZHI, SHI, YING, LIU, XIAOGANG, LI, XUDONG, ZENG, JIN, GONG, YONGGUANG, LI, LEI, WANG, XINYANG, HE, DALIN
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583521/
https://ncbi.nlm.nih.gov/pubmed/26323436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2015.4201
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