Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity

Hepatitis C virus (HCV) variants characterized by genomic deletions in the structural protein region have been sporadically detected in liver and serum of hepatitis C patients. These defective genomes are capable of autonomous RNA replication and are packaged into infectious viral particles in cells...

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Udgivet i:PLoS One
Main Authors: Cheroni, Cristina, Donnici, Lorena, Aghemo, Alessio, Balistreri, Francesca, Bianco, Annalisa, Zanoni, Valeria, Pagani, Massimiliano, Soffredini, Roberta, D’Ambrosio, Roberta, Rumi, Maria Grazia, Colombo, Massimo, Abrignani, Sergio, Neddermann, Petra, De Francesco, Raffaele
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583497/
https://ncbi.nlm.nih.gov/pubmed/26405760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138546
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