Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening

The Plasmodium falciparum PfA-M1 and PfA-M17 metalloaminopeptidases are validated drug targets for the discovery of antimalarial agents. In order to identify dual inhibitors of both proteins, we developed a hierarchical virtual screening approach, followed by in vitro evaluation of the highest scori...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Ruggeri, Chiara, Drinkwater, Nyssa, Sivaraman, Komagal Kannan, Bamert, Rebecca S., McGowan, Sheena, Paiardini, Alessandro
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583420/
https://ncbi.nlm.nih.gov/pubmed/26406322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138957
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker