miRNAs and resistance to EGFR—TKIs in EGFR-mutant non-small cell lung cancer: beyond ‘traditional mechanisms’ of resistance

Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) have dramatically changed the prognosis of advanced non-small cell lung cancers (NSCLCs) that harbour specific EGFR activating mutations. However, the efficacy of an EGFR-TKI is limited by the onset of acquired resistance, usu...

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Enregistré dans:
Détails bibliographiques
Publié dans:Ecancermedicalscience
Auteurs principaux: Ricciuti, Biagio, Mecca, Carmen, Cenci, Matteo, Leonardi, Giulia Costanza, Perrone, Lorenzo, Mencaroni, Clelia, Crinò, Lucio, Grignani, Francesco, Baglivo, Sara, Chiari, Rita, Sidoni, Angelo, Paglialunga, Luca, Currà, Maria Francesca, Murano, Emanuele, Minotti, Vincenzo, Metro, Giulio
Format: Artigo
Langue:Inglês
Publié: Cancer Intelligence 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583238/
https://ncbi.nlm.nih.gov/pubmed/26435742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3332/ecancer.2015.569
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