The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function

Polycystin-2 (PC2) is a TRP-type, Ca(2+)-permeable non-selective cation channel that plays an important role in Ca(2+) signaling in renal and non-renal cells. The effect(s) of the cAMP pathway and kinase mediated phosphorylation of PC2 seem to be relevant to PC2 trafficking and its interaction with...

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Pubblicato in:J Biol Chem
Autori principali: Cantero, María del Rocío, Velázquez, Irina F., Streets, Andrew J., Ong, Albert C. M., Cantiello, Horacio F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Membrane Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583051/
https://ncbi.nlm.nih.gov/pubmed/26269590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.661082
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