Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4(+) T cells

Indoleamine 2,3-dioxygenase (IDO) is expressed in antigen-presenting cells and exerts immunosuppressive effects on CD4(+) T cells. One mechanism is through the inhibition of aerobic glycolysis. Another prerequisite for T-cell proliferation and differentiation into effector cells is increased fatty a...

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Vydáno v:Immunology
Hlavní autoři: Eleftheriadis, Theodoros, Pissas, Georgios, Antoniadi, Georgia, Liakopoulos, Vassilios, Stefanidis, Ioannis
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Ltd 2015
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582970/
https://ncbi.nlm.nih.gov/pubmed/26147366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12502
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