Endogenous sterol metabolites regulate growth of EGFR/KRAS-dependent tumors via LXR

Meiosis activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathway and are important for normal organismal development. Oncogenic transformation by EGFR or RAS increases the demand for cholesterol, suggesting a possibility for metabolic interference. To test this idea in...

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發表在:Cell Rep
Main Authors: Gabitova, Linara, Restifo, Diana, Gorin, Andrey, Manocha, Kunal, Handorf, Elizabeth, Yang, Dong-Hua, Cai, Kathy Q., Klein-Szanto, Andres J., Cunningham, David, Kratz, Lisa E., Herman, Gail E., Golemis, Erica A., Astsaturov, Igor
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581991/
https://ncbi.nlm.nih.gov/pubmed/26344763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.023
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