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Muscle hypertrophy induced by myostatin inhibition accelerates degeneration in dysferlinopathy

Myostatin is a secreted signaling molecule that normally acts to limit muscle growth. As a result, there is extensive effort directed at developing drugs capable of targeting myostatin to treat patients with muscle loss. One potential concern with this therapeutic approach in patients with muscle de...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Lee, Yun-Sil, Lehar, Adam, Sebald, Suzanne, Liu, Min, Swaggart, Kayleigh A., Talbot, C. Conover, Pytel, Peter, Barton, Elisabeth R., McNally, Elizabeth M., Lee, Se-Jin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581601/
https://ncbi.nlm.nih.gov/pubmed/26206886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv288
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