Modification of antisense phosphodiester oligodeoxynucleotides by a 5' cholesteryl moiety increases cellular association and improves efficacy.

Phosphodiester oligodeoxynucleotides bearing a 5' cholesteryl (chol) modification bind to low density lipoprotein (LDL), apparently by partitioning the chol-modified oligonucleotides into the lipid layer. Both HL60 cells and primary mouse spleen T and B cells incubated with fluorescently labele...

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Detalhes bibliográficos
Main Authors: Krieg, A M, Tonkinson, J, Matson, S, Zhao, Q, Saxon, M, Zhang, L M, Bhanja, U, Yakubov, L, Stein, C A
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC45808/
https://ncbi.nlm.nih.gov/pubmed/8430072
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