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Mitochondrial dysfunction in aging: Much progress but many unresolved questions

The free radical theory of aging is almost 60 years old. As mitochondria are the principle source of intracellular reactive oxygen species (ROS), this hypothesis suggested a central role for the mitochondrion in normal mammalian aging. In recent years, however, much work has questioned the importanc...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Payne, Brendan A.I., Chinnery, Patrick F.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Pub. Co 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580208/
https://ncbi.nlm.nih.gov/pubmed/26050973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2015.05.022
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