Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene.

Human tobacco-related cancers exhibit a high frequency of G to T transversions in the mutation hot spot region of the p53 tumor suppressor gene, possibly the result of specific mutagens in tobacco smoke, most notably benzo[a]pyrene (B[a]P). No in vivo animal model of B[a]P-induced tumorigenesis has...

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Detaylı Bibliyografya
Asıl Yazarlar: Ruggeri, B, DiRado, M, Zhang, S Y, Bauer, B, Goodrow, T, Klein-Szanto, A J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1993
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC45801/
https://ncbi.nlm.nih.gov/pubmed/8430068
Etiketler: Etiketle
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