Matrix Metalloproteinase‐2 Negatively Regulates Cardiac Secreted Phospholipase A(2) to Modulate Inflammation and Fever

BACKGROUND: Matrix metalloproteinase (MMP)‐2 deficiency makes humans and mice susceptible to inflammation. Here, we reveal an MMP‐2–mediated mechanism that modulates the inflammatory response via secretory phospholipase A(2) (sPLA(2)), a phospholipid hydrolase that releases fatty acids, including pr...

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Bibliographische Detailangaben
Veröffentlicht in:J Am Heart Assoc
Hauptverfasser: Berry, Evan, Hernandez‐Anzaldo, Samuel, Ghomashchi, Farideh, Lehner, Richard, Murakami, Makoto, Gelb, Michael H., Kassiri, Zamaneh, Wang, Xiang, Fernandez‐Patron, Carlos
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2015
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579961/
https://ncbi.nlm.nih.gov/pubmed/25820137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.001868
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