Light Chain Amyloid Fibrils Cause Metabolic Dysfunction in Human Cardiomyocytes

Light chain (AL) amyloidosis is the most common form of systemic amyloid disease, and cardiomyopathy is a dire consequence, resulting in an extremely poor prognosis. AL is characterized by the production of monoclonal free light chains that deposit as amyloid fibrils principally in the heart, liver,...

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Udgivet i:PLoS One
Main Authors: McWilliams-Koeppen, Helen P., Foster, James S., Hackenbrack, Nicole, Ramirez-Alvarado, Marina, Donohoe, Dallas, Williams, Angela, Macy, Sallie, Wooliver, Craig, Wortham, Dale, Morrell-Falvey, Jennifer, Foster, Carmen M., Kennel, Stephen J., Wall, Jonathan S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579077/
https://ncbi.nlm.nih.gov/pubmed/26393799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137716
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