Melanoma brain metastasis is independent of lactate dehydrogenase A expression

BACKGROUND: The key metabolic enzyme lactate dehydrogenase A (LDHA) is overexpressed in many cancers, and several preclinical studies have shown encouraging results of targeted inhibition. However, the mechanistic importance of LDHA in melanoma is largely unknown and hitherto unexplored in brain met...

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發表在:Neuro Oncol
Main Authors: Sundstrøm, Terje, Espedal, Heidi, Harter, Patrick N., Fasmer, Kristine Eldevik, Skaftnesmo, Kai Ove, Horn, Sindre, Hodneland, Erlend, Mittelbronn, Michel, Weide, Benjamin, Beschorner, Rudi, Bender, Benjamin, Rygh, Cecilie Brekke, Lund-Johansen, Morten, Bjerkvig, Rolf, Thorsen, Frits
格式: Artigo
語言:Inglês
出版: Oxford University Press 2015
主題:
Basic and Translational Investigations
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578581/
https://ncbi.nlm.nih.gov/pubmed/25791837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov040
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