Expression of a constitutively active erythropoietin receptor in primary hematopoietic progenitors abrogates erythropoietin dependence and enhances erythroid colony-forming unit, erythroid burst-forming unit, and granulocyte/macrophage progenitor growth.

We tested the ability of a constitutively activated erythropoietin receptor [EpoR(R129C)] to alter the growth requirements of primary hematopoietic precursors that terminally differentiate in culture. Two recombinant retroviruses expressing EpoR(R129C), spleen focus-forming virus (SFFVc-EpoR) and my...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pharr, P N, Hankins, D, Hofbauer, A, Lodish, H F, Longmore, G D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45785/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7679218/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.3.938
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!