Efficacy of the Herpes Simplex Virus 2 (HSV-2) Glycoprotein D/AS04 Vaccine against Genital HSV-2 and HSV-1 Infection and Disease in the Cotton Rat Sigmodon hispidus Model

Subunit vaccines based on the herpes simplex virus 2 (HSV-2) glycoprotein D (gD-2) have been the major focus of HSV-2 vaccine development for the past 2 decades. Based on the promising data generated in the guinea pig model, a formulation containing truncated gD-2, aluminum salt, and MPL (gD/AS04) a...

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Bibliographic Details
Published in:J Virol
Main Authors: Boukhvalova, Marina, McKay, Jamall, Mbaye, Aissatou, Sanford-Crane, Hannah, Blanco, Jorge C. G., Huber, Ashley, Herold, Betsy C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577902/
https://ncbi.nlm.nih.gov/pubmed/26178984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01387-15
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