A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4–ERK5 axis

Although IL-17 is emerging as an important cytokine in cancer promotion and progression, the underlining molecular mechanism remains unclear. Previous studies suggest that IL-17 (IL-17A) sustains a chronic inflammatory microenvironment that favors tumor formation. Here we report a novel IL-17–mediat...

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Publicado no:J Exp Med
Main Authors: Wu, Ling, Chen, Xing, Zhao, Junjie, Martin, Bradley, Zepp, Jarod A., Ko, Jennifer S., Gu, Chunfang, Cai, Gang, Ouyang, Wenjun, Sen, Ganes, Stark, George R., Su, Bing, Vines, Charlotte M., Tournier, Cathy, Hamilton, Thomas A., Vidimos, Allison, Gastman, Brian, Liu, Caini, Li, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577838/
https://ncbi.nlm.nih.gov/pubmed/26347473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150204
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